Evaluation of pulmonary artery pressure in patients with juvenile systemic lupus erythematosus (jSLE)

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dc.contributor.authorAdrovic, Amra
dc.contributor.authorDedeoğlu, Reyhan
dc.contributor.authorŞahin, Sezgin
dc.contributor.authorBarut, Kenan
dc.contributor.authorKoka, Aida
dc.contributor.authorCengiz, Dicle
dc.contributor.authorKasapçopur, Özgür
dc.date.accessioned2020-11-21T15:54:04Z
dc.date.available2020-11-21T15:54:04Z
dc.date.issued2018en_US
dc.departmentİstanbul Ticaret Üniversitesien_US
dc.descriptionPubMed ID: 28704174en_US
dc.description.abstractJuvenile systemic lupus erythematosus (jSLE) is a chronic multisystemic autoimmune disease. Previous studies among adults have shown impaired right ventricular (RV) function in patients with SLE. Also, these patients may develop pulmonary artery hypertension (PAH), which is one of the most threatening complications of SLE. Nevertheless, studies on PAH among jSLE patients are still rare. The aim of this study was to assess the RV function in jSLE patients by Doppler echocardiography (Echo Doppler). We also estimated pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressure (mPAP) in these patients. A total of 38 jSLE patients and 40 sex- and age-matched controls were retrospectively analyzed. All patients underwent combined M-mode, cross-sectional echo, and Doppler Echo examination. The RV function was significantly impaired in jSLE patients compared to controls. PASP and mPAP were normal in 37 out of 38 patients (97.37%), however, the mean values of PASP and mPAP were significantly higher in jSLE patients compared to controls (26.90 mmHg versus 21.71 mmHg and 12.63 mmHg versus 9.89 mmHg, respectively) [p < 0.05]. Only one patient (2.6 %) had elevated mPAP (60 mmHg). The right cardiac catheterization confirmed PAH in this patient. Although PAH was detected only in one patient, there was a marked increase of PAP in our jSLE patients. Overall, PASP and mPAP were significantly higher in jSLE patients compared to healthy controls. Prospective studies with ethnically diverse cohorts could give more insight on the relevance of PAP and PHT in patients with jSLE. © 2018 ABMSFBIH.en_US
dc.identifier.doi10.17305/bjbms.2017.2178en_US
dc.identifier.endpage71en_US
dc.identifier.issn1512-8601
dc.identifier.issue1en_US
dc.identifier.pmid28704174en_US
dc.identifier.scopus2-s2.0-85042755411en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://doi.org/10.17305/bjbms.2017.2178
dc.identifier.urihttps://hdl.handle.net/11467/3752
dc.identifier.volume18en_US
dc.identifier.wosWOS:000426444900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssociation of Basic Medical Sciences of FBIHen_US
dc.relation.ispartofBosnian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDoppler echocardiographyen_US
dc.subjectjSLEen_US
dc.subjectJuvenile systemic lupus erythematosusen_US
dc.subjectmPAPen_US
dc.subjectPAHen_US
dc.subjectPAPen_US
dc.subjectPASPen_US
dc.subjectPulmonary artery hypertensionen_US
dc.subjectPulmonary artery pressureen_US
dc.subjectRight ventricleen_US
dc.titleEvaluation of pulmonary artery pressure in patients with juvenile systemic lupus erythematosus (jSLE)en_US
dc.typeArticleen_US

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