Evaluation of pulmonary artery pressure in patients with juvenile systemic lupus erythematosus (jSLE)
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Association of Basic Medical Sciences of FBIH
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Juvenile systemic lupus erythematosus (jSLE) is a chronic multisystemic autoimmune disease. Previous studies among adults have shown impaired right ventricular (RV) function in patients with SLE. Also, these patients may develop pulmonary artery hypertension (PAH), which is one of the most threatening complications of SLE. Nevertheless, studies on PAH among jSLE patients are still rare. The aim of this study was to assess the RV function in jSLE patients by Doppler echocardiography (Echo Doppler). We also estimated pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressure (mPAP) in these patients. A total of 38 jSLE patients and 40 sex- and age-matched controls were retrospectively analyzed. All patients underwent combined M-mode, cross-sectional echo, and Doppler Echo examination. The RV function was significantly impaired in jSLE patients compared to controls. PASP and mPAP were normal in 37 out of 38 patients (97.37%), however, the mean values of PASP and mPAP were significantly higher in jSLE patients compared to controls (26.90 mmHg versus 21.71 mmHg and 12.63 mmHg versus 9.89 mmHg, respectively) [p < 0.05]. Only one patient (2.6 %) had elevated mPAP (60 mmHg). The right cardiac catheterization confirmed PAH in this patient. Although PAH was detected only in one patient, there was a marked increase of PAP in our jSLE patients. Overall, PASP and mPAP were significantly higher in jSLE patients compared to healthy controls. Prospective studies with ethnically diverse cohorts could give more insight on the relevance of PAP and PHT in patients with jSLE. © 2018 ABMSFBIH.
Açıklama
PubMed ID: 28704174
Anahtar Kelimeler
Doppler echocardiography, jSLE, Juvenile systemic lupus erythematosus, mPAP, PAH, PAP, PASP, Pulmonary artery hypertension, Pulmonary artery pressure, Right ventricle
Kaynak
Bosnian Journal of Basic Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
18
Sayı
1
