Self-assembly of phenylalanine-based molecules
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
American Chemical Society
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Using molecular dynamics, we study the self-assembly of phenylalanine with charged end-groups at various temperatures and concentrations. As in the case of diphenylalanine, we observe the formation of nanotubes; however, phenylalanine aggregates in layers of four, not six, molecules. The observed aggregates are consistent with recent experimental measurements of fibrils obtained from mice with phenylketonuria. We investigate the stability and the mechanism by which these tubular structures form and discuss potential toxicity mechanisms. © 2014 American Chemical Society.
Açıklama
PubMed ID: 25347763
Anahtar Kelimeler
Kaynak
Journal of Physical Chemistry A
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
119
Sayı
9
