Electrocardiography changes in bipolar patients during long-term lithium monotherapy

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dc.authoridGuloksuz, Sinan/0000-0002-6626-1874
dc.contributor.authorAltinbas, Kursat
dc.contributor.authorGuloksuz, Sinan
dc.contributor.authorCaglar, Ilker Murat
dc.contributor.authorCaglar, Fatma Nihan Turhan
dc.contributor.authorKurt, Erhan
dc.contributor.authorOral, Esat Timucin
dc.date.accessioned2024-10-12T19:42:55Z
dc.date.available2024-10-12T19:42:55Z
dc.date.issued2014
dc.departmentİstanbul Ticaret Üniversitesien_US
dc.description.abstractObjective: Cardiovascular side effects of lithium have been reported to occur mainly at higher-than-therapeutic serum levels. We aimed to investigate the impact of the long-term lithium use on electrocardiogram (ECG) parameters in association with the serum levels in patients with bipolar disorder (BD) and in healthy controls (HCs) serving as the reference group. Methods: The study sample consisted of 53 euthymic BD type I patients on lithium monotherapy at therapeutic serum levels (M=0.76, S.D.=0.14, range=0.41-1.09 mmol/l) for at least 12 months and 45 HCs. A 12-lead surface ECG was obtained from all participants at resting state for at least half an hour for 5-min recording. Heart-rate, Pmax, Pmin, QRS interval, QT dispersion, QT dispersion ratio (QTdR) and Tpeak-to-end interval (TpTe) were measured. Results: Regression analyses revealed that QTdR (B=14.17, P=.001), TpTe (B=18.38, P<.001), Pmax (B=17.84, P<.001) and Pmin (B=25.10, P<.001) were increased in BD patients who were on chronic lithium treatment than in HCs after controlling for age, sex and strict Bonferroni correction for multiple testing. There were no associations between serum lithium levels and ECG parameters. Conclusion: Our findings suggest that the use of lithium is associated with both atrial and ventricular electrical instability, even when lithium levels are in the therapeutic range. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipEuropean Community [HEALTH-F2-2009-241909]en_US
dc.description.sponsorshipWe would like to thank Prof. Willem Nolen who kindly reviewed the article and shared his comments on the article. S. G. would like to thank the support of the European Community's Seventh Framework Programme under grant agreement no. HEALTH-F2-2009-241909 (Project EU-GEI).en_US
dc.identifier.doi10.1016/j.genhosppsych.2014.07.001
dc.identifier.endpage697en_US
dc.identifier.issn0163-8343
dc.identifier.issn1873-7714
dc.identifier.issue6en_US
dc.identifier.pmid25091141en_US
dc.identifier.startpage694en_US
dc.identifier.urihttps://doi.org/10.1016/j.genhosppsych.2014.07.001
dc.identifier.urihttps://hdl.handle.net/11467/8661
dc.identifier.volume36en_US
dc.identifier.wosWOS:000345434400026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofGeneral Hospital Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzWoS_2024en_US
dc.subjectBipolar disorderen_US
dc.subjectLithiumen_US
dc.subjectECGen_US
dc.subjectQT intervalen_US
dc.subjectArrhythmiaen_US
dc.titleElectrocardiography changes in bipolar patients during long-term lithium monotherapyen_US
dc.typeArticleen_US

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