Evaluation of cardiac functions in juvenile systemic lupus erythematosus with two-dimensional speckle tracking echocardiography

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dc.contributor.authorDedeoğlu, Reyhan
dc.contributor.authorŞahin, Sezgin
dc.contributor.authorKoka, Aida
dc.contributor.authorÖztunç, Funda
dc.contributor.authorCengiz, Dicle
dc.contributor.authorBarut, Kenan
dc.contributor.authorKasapçopur, Özgür
dc.date.accessioned2020-11-21T15:53:30Z
dc.date.available2020-11-21T15:53:30Z
dc.date.issued2016en_US
dc.departmentİstanbul Ticaret Üniversitesien_US
dc.descriptionPubMed ID: 27139514en_US
dc.description.abstractThe aim of this study was to investigate subclinical systolic and diastolic dysfunction in juvenile-onset systemic lupus erythematosus (j-SLE) patients with speckle tracking echocardiography (STE) and the effects of disease activity on left ventricular (LV) regional functions. Thirty-five patients with j-SLE and 30 healthy children (control group) were evaluated between January and August 2015. STE was performed on all patients and controls. Medical records, including diagnosis criteria, age at diagnosis, and duration of disease, were evaluated. SLE disease activity was assessed using the SLE Disease Activity Index (SLEDAI). j-SLE patients had lower ejection fraction than did control subjects but still within normal range. LV end-diastolic and end-systolic dimensions were significantly larger in j-SLE patients (32.43 ± 3.2 vs 28.3 ± 3.1 and 21.1 ± 1.9 vs 18.9.0 ± 2.2, respectively; p = 0.001). There was a significant reduction in longitudinal strain of LV segments in the j-SLE patients compared with controls. J-SLE patients were further divided into subgroups. Group 1 comprised patients having SLEDAI scores >8 at the onset of disease but who improved with therapy during follow-up. Group 2 included j-SLE patients with SLEDAI scores >8 at diagnosis and persistently >4 at the end of follow-up. In the LV mid-inferior and mid-inferolateral segments, STE strain measurements of group 2 were significantly lower than those of group 1 (15.9 ± 6.4 vs 20.0 ± 4.4, 17.9 ± 7.2 vs 23.2 ± 3.8; p = 0.075, p = 0.055, respectively). Simple and non-invasive STE would be helpful in predicting cardiovascular prognosis with new therapeutic medications/interventions or in objectively comparing the effects of immunosuppressive drugs in comparison with preceding STE evaluation. © 2016, International League of Associations for Rheumatology (ILAR).en_US
dc.identifier.doi10.1007/s10067-016-3289-7en_US
dc.identifier.endpage1975en_US
dc.identifier.issn0770-3198
dc.identifier.issue8en_US
dc.identifier.pmid27139514en_US
dc.identifier.scopus2-s2.0-84965079414en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1967en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-016-3289-7
dc.identifier.urihttps://hdl.handle.net/11467/3608
dc.identifier.volume35en_US
dc.identifier.wosWOS:000380265100011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Londonen_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectj-SLEen_US
dc.subjectSLEDAIen_US
dc.subjectSpeckle tracking echocardiographyen_US
dc.subjectSystolic dysfunctionen_US
dc.subjectSystolic strainen_US
dc.titleEvaluation of cardiac functions in juvenile systemic lupus erythematosus with two-dimensional speckle tracking echocardiographyen_US
dc.typeArticleen_US

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