Asymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: Correlation with tumor necrosis factor-? (TNF-?) and 8-iso-prostaglandin F2? (8-iso-PGF2?)

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dc.contributor.authorTopal, Gökçe
dc.contributor.authorDönmez, Arif
dc.contributor.authorUydeş-Doğan, B.Sönmez
dc.contributor.authorKucur, Mine
dc.contributor.authorCengiz, Dicle
dc.contributor.authorBerkoz, Fatma Begüm
dc.contributor.authorErdoğan, Nergis
dc.date.accessioned2020-11-21T15:51:42Z
dc.date.available2020-11-21T15:51:42Z
dc.date.issued2011en_US
dc.departmentİstanbul Ticaret Üniversitesien_US
dc.descriptionPubMed ID: 21291875en_US
dc.description.abstractObjective: The aim of the study was to investigate serum levels of asymmetric dimethylarginine (ADMA), tumor necrosis factor-? (TNF-?), interleukin-6 (IL-6) and plasma levels of 8-iso-prostaglandin F2? (8-iso-PGF2?) in patients with fibromyalgia. Design and method: Twenty-seven patients with fibromyalgia and twenty healthy controls were enrolled in this study. ADMA, TNF-?, IL-6 and 8-iso-PGF2? levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of ADMA and TNF-? and plasma levels 8-iso-PGF2? were significantly increased in patients with fibromyalgia compared to controls. However, no significant difference was observed in IL-6 levels between the two groups. ADMA concentrations were positively correlated with TNF-? and 8-iso-PGF2? levels in patients with fibromyalgia. Conclusion: This is the first study reporting that ADMA levels are significantly elevated in patients with fibromyalgia in association with increased 8-iso-PGF2? and TNF-? concentrations. Thereby, ADMA could be suggested as a reliable marker of endothelial dysfunction in patients with fibromyalgia. © 2011 The Canadian Society of Clinical Chemists.en_US
dc.identifier.doi10.1016/j.clinbiochem.2011.01.011en_US
dc.identifier.endpage367en_US
dc.identifier.issn0009-9120
dc.identifier.issue05.Junen_US
dc.identifier.pmid21291875en_US
dc.identifier.scopus2-s2.0-79952741882en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage364en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2011.01.011
dc.identifier.urihttps://hdl.handle.net/11467/3498
dc.identifier.volume44en_US
dc.identifier.wosWOS:000288845000003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofClinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject8-iso-PGF2?en_US
dc.subjectADMAen_US
dc.subjectFibromyalgiaen_US
dc.subjectIL-6en_US
dc.subjectTNF-?en_US
dc.titleAsymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: Correlation with tumor necrosis factor-? (TNF-?) and 8-iso-prostaglandin F2? (8-iso-PGF2?)en_US
dc.typeArticleen_US

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