Detection of early right ventricular dysfunction in young patients with thalassemia major using tissue doppler imaging

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dc.contributor.authorBornaun H.
dc.contributor.authorDedeoğlu, Reyhan
dc.contributor.authorOztarhan, K.
dc.contributor.authorDedeoğlu, S.
dc.contributor.authorErfidan, E.
dc.contributor.authorGündoğdu, M.
dc.contributor.authorCengiz, Dicle
dc.date.accessioned2020-11-21T15:54:26Z
dc.date.available2020-11-21T15:54:26Z
dc.date.issued2016en_US
dc.departmentİstanbul Ticaret Üniversitesien_US
dc.description.abstractBackground: Myocardial iron overload is the mostcommoncause of mortality in patients with thalassemia major (TM), alsoknown as beta-thalassemia. T2* cardiovascular magnetic resonance imaging (MRI) is the best way of monitoring cardiac iron, and new echocardiographic techniques can be used to assess cardiac function. Objectives: The aim of this study was to assess the systolic and diastolic right ventricular (RV) function of patients with TM using tissue Doppler imaging (TDI) and to determine whether this echocardiographic technique is an adequate diagnostic tool for the screening and detection of subclinical cardiac dysfunction. Patients and Methods: Eighty-four patients with TM were evaluated by conventional echocardiography and pulse-wave TDI. The data of the TM group (Group 1) were compared with that of 85 age-and sex-matched healthy controls (Group 2). Cardiovascular T2* MRI examinations were performed in 49 of the 85 patients. Results: The patients with TM had significantly lower values for weight, height, body mass index, systolic arterial pressure, deceleration time, E’/A’, and ejection time (ET) than the controls. Group 1 also had significantly higher values for peak early diastolic velocity (E) over peak late diastolic velocity (A), peak early diastolic velocity of TDI (E’), peak late diastolic velocity of TDI (A’), E/E’, isovolumetric relaxation time, isovolumetric contraction time, and RV magnetic perfusion imaging (MPI) than Group 2. Conclusions: RV diastolic dysfunction occurs before systolic deterioration in patients with TM and cannot be screened with conventional echocardiographic techniques. In routine practice, TDI measurements, MPI (for global function) and the E/E’ parameter (for diastolic function) can be used to screen and detect early RV dysfunction. © 2016, Growth & Development Research Center.en_US
dc.identifier.doi10.5812/ijp.5808en_US
dc.identifier.issn2008-2142
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84983070441en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.5812/ijp.5808
dc.identifier.urihttps://hdl.handle.net/11467/3830
dc.identifier.volume26en_US
dc.identifier.wosWOS:000384931800015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTehran University of Medical Sciences (TUMS)en_US
dc.relation.ispartofIranian Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeta-Thalassemiaen_US
dc.subjectEchocardiographyen_US
dc.subjectVentricular Functionen_US
dc.subjectYoung Patientsen_US
dc.titleDetection of early right ventricular dysfunction in young patients with thalassemia major using tissue doppler imagingen_US
dc.typeArticleen_US

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