Minor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodes

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dc.contributor.authorİnce, Bahri
dc.contributor.authorGülöksüz, Sinan
dc.contributor.authorAltınbaş, Kürşat
dc.contributor.authorOral, E. Timuçin
dc.contributor.authorAlpkan, Latif Ruhşat
dc.contributor.authorAltınöz, Meriç A.
dc.date.accessioned2020-11-21T15:53:22Z
dc.date.available2020-11-21T15:53:22Z
dc.date.issued2013en_US
dc.departmentİstanbul Ticaret Üniversitesien_US
dc.descriptionPubMed ID: 23856286en_US
dc.description.abstractBackground: There exist studies indicating that bipolar disorder (BD) associates with changes in brain blood flow. Human brain with its high demand to oxygen constitutes 2% of the total body weight, while it receives 20% of cardiac output. and 3 globin chains of hemoglobin were recently found in neural tissues, yet no study has questioned blood hemoglobins in BR Methods: A total of 120 euthymic BD patients (40 males and 80 females) were analyzed via high performance liquid chromatography (HPLC) to measure minor hemoglobin levels, which were statistically compared with disease characteristics. Results: Minor hemoglobins HbA2 and HbF associated positively with episode density as a measure of disease severity in BR An increased level of HbA2 meant significantly less postpartum episodes in child bearing women. HbF levels were higher in patients with a positive family history of any psychotic disorder. Sum of HbA2 and HbF correlated with episode density with a stronger significance (p <0001) supporting intermittent hypoxia hypothesis in BR Limitations: The study was conducted only on euthymic patients to avoid likely bigger exogenous effects such as electro-convulsive therapy and diverse drug regimes, yet larger comparative studies are needed to support our current findings. Conclusions: Higher HbA2 and HbF in more severe bipolar disorder may be compensations against intermittent hypoxias in BR HbA2 increases following myocardial angina and in mountain dwellers, which may indicate protective roles in extreme conditions. HbF increase may act more as a maladaptation or emerge via haplotypal associations of BD genes and gamma-globin locus at II p155. © 2013 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jad.2013.06.042en_US
dc.identifier.endpage408en_US
dc.identifier.issn0165-0327
dc.identifier.issue1en_US
dc.identifier.pmid23856286en_US
dc.identifier.scopus2-s2.0-84888639256en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.1016/j.jad.2013.06.042
dc.identifier.urihttps://hdl.handle.net/11467/3562
dc.identifier.volume151en_US
dc.identifier.wosWOS:000324039500057en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Affective Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar disorderen_US
dc.subjectEpisode densityen_US
dc.subjectFetal hemoglobinen_US
dc.subjectHemoglobin A2en_US
dc.subjectIntermittent hypoxiaen_US
dc.subjectPostpartum episodeen_US
dc.titleMinor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodesen_US
dc.typeArticleen_US

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