Evidence for an association between tumor necrosis factor-alpha levels and lithium response

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dc.contributor.authorGülöksüz, Sinan
dc.contributor.authorAltınbaş, Kürşat
dc.contributor.authorAktaş, Çetin E.
dc.contributor.authorKenis, Gunter
dc.contributor.authorBilgiç Gazioğlu, Sema
dc.contributor.authorDeniz, Günnur
dc.contributor.authorOs, J. Van
dc.date.accessioned2020-11-21T15:53:22Z
dc.date.available2020-11-21T15:53:22Z
dc.date.issued2012en_US
dc.departmentİstanbul Ticaret Üniversitesien_US
dc.descriptionPubMed ID: 22749155en_US
dc.description.abstractBackground: The role of inflammation in bipolar disorder has recently emerged as a potential pathophysiological mechanism. Tumor necrosis factor-alpha (TNF-?) modulation may represent a pathogenic molecular target and a biomarker for staging bipolar disorder. In this context, the possible association between lithium response and TNF-? level was examined. Methods: Sixty euthymic bipolar patients receiving lithium therapy were recruited for assessment of TNF-? level. The ALDA lithium response scale (LRS) was used to evaluate longitudinal lithium response in bipolar patients, using cut-offs of poor response, partial response and good response. TNF-? level was assessed using enzyme-linked immunosorbent assay. Results: There was a significant increase in TNF-? level in patients with poor lithium response compared to those with good response, also after controlling for a range of potential confounders (adjusted effect size: 0.47, p=0.011). Partial response showed a directionally similar, but attenuated and statistically inconclusive association (adjusted effect size: 0.16, p=0.326). Limitations: Assessment of response was retrospective and natural course cannot be separated easily from treatment response in an observational design. Selection of additional inflammatory markers could provide for a better understanding of underlying immune changes. Conclusions: This study strengthens the hypothesis that TNF-? level may mark or mediate lithium response, and that continuous immune imbalance in poor lithium responders may occasion treatment resistance. Further investigation of immune alterations in treatment-resistant bipolar patients may be productive. © 2012 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.jad.2012.04.044en_US
dc.identifier.endpage152en_US
dc.identifier.issn0165-0327
dc.identifier.issue01.Maren_US
dc.identifier.pmid22749155en_US
dc.identifier.scopus2-s2.0-84869506512en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://doi.org/10.1016/j.jad.2012.04.044
dc.identifier.urihttps://hdl.handle.net/11467/3561
dc.identifier.volume143en_US
dc.identifier.wosWOS:000311213800021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Affective Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar disorderen_US
dc.subjectCytokineen_US
dc.subjectInflammationen_US
dc.subjectLithiumen_US
dc.subjectTreatmenten_US
dc.subjectTumor necrosis factoren_US
dc.titleEvidence for an association between tumor necrosis factor-alpha levels and lithium responseen_US
dc.typeArticleen_US

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