Cytokine levels in euthymic bipolar patients

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dc.contributor.authorGülöksüz, Sinan
dc.contributor.authorAktaş, Çetin E.
dc.contributor.authorÇetin, Turan
dc.contributor.authorDeniz, Günnur
dc.contributor.authorOral, E. Timuçin
dc.contributor.authorNutt, David J.
dc.date.accessioned2020-11-21T15:53:22Z
dc.date.available2020-11-21T15:53:22Z
dc.date.issued2010en_US
dc.departmentİstanbul Ticaret Üniversitesien_US
dc.descriptionPubMed ID: 20537397en_US
dc.description.abstractBackground: The pathophysiology of bipolar disorder is not thoroughly understood. Several studies have investigated the possible role of cytokines in psychiatric disorders, based on their role in neuro-immune modulation; however, findings in studies on bipolar disorder remain limited and contradictory, and most studies have focused on either manic or depressive episodes. These studies suggest that both manic and depressive episodes could be pro-inflammatory states. The present study aimed to determine whether there are enduring differences in cytokine levels-unrelated to the effects of medication-between euthymic bipolar patients and healthy controls. Methods: The study included 31 euthymic bipolar patients-16 medication-free (MF) and 15 on lithium monotherapy (LM) and 16 healthy volunteers in whom serum cytokine levels were measured. The 3 groups were homogenous in terms of age, gender, and ethnicity. IFN-?, TNF-?, IL-2, IL-4, IL-5, and IL-10 levels were measured in all groups using flow cytometry. Results: There were no differences in cytokine levels between MF euthymic bipolar patients and healthy controls. TNF-? and IL-4 levels in LM euthymic bipolar patients were higher than in both the MF euthymic bipolar patients and controls. Limitations: The small and strictly selected study sample could limit the generalizability of the findings. Conclusions: Cytokine production in MF euthymic bipolar patients was similar to that in healthy controls. The present study shows that the pro-inflammatory state resolves in euthymia and that lithium had an influence on the cytokine profile, which could create a confounding factor while investigating disease- related immunopathology of bipolar disorder. © 2010 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jad.2010.04.027en_US
dc.identifier.endpage462en_US
dc.identifier.issn0165-0327
dc.identifier.issue3en_US
dc.identifier.pmid20537397en_US
dc.identifier.scopus2-s2.0-77957369600en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage458en_US
dc.identifier.urihttps://doi.org/10.1016/j.jad.2010.04.027
dc.identifier.urihttps://hdl.handle.net/11467/3560
dc.identifier.volume126en_US
dc.identifier.wosWOS:000283901300016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Affective Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar disorderen_US
dc.subjectCytokinesen_US
dc.subjectEuthymicen_US
dc.subjectInflammationen_US
dc.subjectInterleukinen_US
dc.subjectTumor necrosis factoren_US
dc.titleCytokine levels in euthymic bipolar patientsen_US
dc.typeArticleen_US

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