Comparable efficacy of tenofovir versus entecavir and predictors of response in treatment-naïve patients with chronic hepatitis B: A multicenter real-life study

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dc.contributor.authorBatirel, Ayse
dc.contributor.authorGuclu, Ertugrul
dc.contributor.authorArslan, Ferhat
dc.contributor.authorKocak, Funda
dc.contributor.authorKarabay, Oguz
dc.contributor.authorOzer, Serdar
dc.contributor.authorTuranli, Munevver
dc.date.accessioned2024-10-12T19:47:12Z
dc.date.available2024-10-12T19:47:12Z
dc.date.issued2014
dc.departmentİstanbul Ticaret Üniversitesien_US
dc.description.abstractObjective: To compare responses to tenofovir (TDF) and entecavir (ETV) therapy. Methods: This was a multicenter retrospective study including treatment-naïve patients with chronic hepatitis B (CHB) who received TDF or ETV. The primary end-points were undetectable HBV-DNA at 48 weeks and serological and biochemical responses. Results: Out of 195 CHB patients, 90 (46%) received TDF and 105 (54%) received ETV; 72% were male, their mean age was 43. ±. 12 years, and the mean duration of treatment was 30.2. ±. 15.7 months. Hepatitis B e antigen (HBeAg) seropositivity was 32% in the TDF group and 34% in the ETV group. HBeAg seroconversion rates in HBeAg-positive patients were 24% in the TDF group and 39% in the ETV group; the difference was not significant (. p=. 0.2). The mean time to alanine aminotransferase (ALT) normalization and rates of ALT normalization at 3, 6, 12, 18, and 24 months were similar in the two groups (. p > 0.05). The mean time to undetectable HBV-DNA levels in the TDF and ETV groups was 11.5. ±. 8.9 and 12.9. ±. 10.8 months, respectively (. p=. 0.32). A significantly greater decline in HBV-DNA levels at 12 and 18 months was observed in the TDF group (. p=. 0.02 and p=. 0.03, respectively). Seven (7%) patients on ETV therapy had virological breakthrough (. p=. 0.01). Only one patient in each group had hepatitis B surface antigen (HBsAg) clearance. None of the patients developed decompensation or hepatocellular carcinoma during treatment. Conclusions: The two drugs appear to have similar efficacy in CHB patients. However, 7% of patients on ETV therapy had virological breakthrough, while none of the patients on TDF therapy did. © 2014 The Authors.en_US
dc.identifier.doi10.1016/j.ijid.2014.09.004
dc.identifier.endpage159en_US
dc.identifier.issn1201-9712
dc.identifier.pmid25286184en_US
dc.identifier.scopus2-s2.0-84949115549en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2014.09.004
dc.identifier.urihttps://hdl.handle.net/11467/8812
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofInternational Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzScopus_20241012en_US
dc.subjectChronic hepatitis Ben_US
dc.subjectEntecaviren_US
dc.subjectHBVen_US
dc.subjectTenofoviren_US
dc.subjectTreatmenten_US
dc.titleComparable efficacy of tenofovir versus entecavir and predictors of response in treatment-naïve patients with chronic hepatitis B: A multicenter real-life studyen_US
dc.typeArticleen_US

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