Reduced toxicity of protein/magnetic targeted drug delivery system for improved skin cancer treatment in mice model

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dc.contributor.authorCeylan, Muhammet
dc.contributor.authorMisak, Heath E.
dc.contributor.authorStrong, Nora
dc.contributor.authorYang, Shang-you
dc.date.accessioned2022-01-27T11:02:37Z
dc.date.available2022-01-27T11:02:37Z
dc.date.issued2021en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Mekatronik Mühendisliği Bölümüen_US
dc.description.abstractSkin cancer is one of the most common types of cancers. Although majority of skin cancers can be treated effectively if they are diagnosed at an early stage, delayed treatment for some types, such as melanoma, are life threatening. This current study evaluated the therapeutic effects of a recently developed targeted drug delivery system (DDS) to treat an experimental skin squamous cell carcinoma (SCC) in a mouse model. This DDS can release drugs into the body at a designated rate and location. The system consists of biodegradable polymer microspheres of encapsulated magnetic nanoparticles, human albumin, and 5-fluorouracil (5-FU). While the magnetic forces keep the nanocomposite spheres in the targeted cancer area, the protein promotes increased absorption of the DDS near cancer cells to release the therapeutic agent. While tumor sizes were significantly decreased and cancer tissue underwent dramatic necrosis, no remote organ and lymph node metastasis were observed. The tissue specimens collected from vital organs (lungs, liver, kidneys, and lymph nodes adjcent to the cancer sites) were histologically examined and did not showobvious damages and adverse tissue responses after the DDS injections. Overall, this study confirmed that this DDS is successful in treating cancer without toxic effects and may be a possible alternative to traditional therapies.en_US
dc.identifier.doi10.1016/j.jmmm.2021.168404en_US
dc.identifier.scopus2-s2.0-85113144249en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://hdl.handle.net/11467/5165
dc.identifier.urihttps://doi.org/10.1016/j.jmmm.2021.168404
dc.identifier.volume539en_US
dc.identifier.wosWOS:000705024700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Magnetism and Magnetic Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectDrug deliveryen_US
dc.subjectSkin canceren_US
dc.subjectToxicityen_US
dc.subjectTreatmenten_US
dc.titleReduced toxicity of protein/magnetic targeted drug delivery system for improved skin cancer treatment in mice modelen_US
dc.typeArticleen_US

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