Effects Of Gentamicin Loaded Pcl Nanofibers To Cell Viability And Release Rate Of Plasmid Dna

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dc.contributor.authorCeylan, Muhammet
dc.contributor.authorYang, Shang You
dc.contributor.authorAsmatulu, Ramazan
dc.date.accessioned2021-01-25T21:48:13Z
dc.date.available2021-01-25T21:48:13Z
dc.date.issued2020
dc.departmentÄ°stanbul Ticaret Ãœniversitesien_US
dc.description.abstractPolycaprolactone (PCL) nanofiber with constant plasmid DNA addition and with different concentration of gentamicin designed and studied for their effect on cell viability and release rate. PCL nanofibers were fabricated using electrospinning method with plasmid DNA and gentamicin addition. The plasmid DNA used in PCL nanofiber were extracted from E. coli. The scanning electron microscopy (SEM) images show that the nano-scale fiber structures have an average diameter of 113.9 nm. UV microplate reader confirmed the existence of plasmid DNA in the PCL nanofibers. Elisa reader study showed the addition of gentamicin in the fibers. Cell viability tests indicated that PCL nanofibers with 10% gentamicin on a fibroblast cell showed high cell viability, which is related to surface areas and pore size of the electrospun fibers besides to the interaction among gentamicin, plasmid DNA and electrospun fiber matrix.en_US
dc.identifier.doi10.20290/estubtdb.658998en_US
dc.identifier.endpage302en_US
dc.identifier.issn2146-0272
dc.identifier.issn2667-419X
dc.identifier.issue2en_US
dc.identifier.startpage293en_US
dc.identifier.trdizinid390175en_US
dc.identifier.urihttps://doi.org10.20290/estubtdb.658998
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXprd01UYzFOUT09
dc.identifier.urihttps://hdl.handle.net/11467/4561
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEskiÅŸehir Teknik Ãœniversitesi Bilim ve Teknoloji Dergisi b- Teorik Bilimleren_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects Of Gentamicin Loaded Pcl Nanofibers To Cell Viability And Release Rate Of Plasmid Dnaen_US
dc.typeArticleen_US

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