Effects of gentamicin-loaded PCL nanofibers on growth of Gram positive and Gram negative bacteria

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dc.authorid0000-0001-6933-2917en_US
dc.contributor.authorCeylan, Muhammet
dc.contributor.authorYang, Shang-You
dc.contributor.authorAsmatulu, Ramazan
dc.date.accessioned2019-08-20T07:56:33Z
dc.date.available2019-08-20T07:56:33Z
dc.date.issued2017en_US
dc.departmentFakülteler, Mühendislik Fakültesien_US
dc.description.abstractPoly-?-caprolactones (PCLs) incorporated with gentamicin of different concentrations (0, 2.5, 5 and 10 wt.%) were electrospun under various conditions, and the resultant nanofibers of different thicknesses (1, 2 and 4 layers) were used against the growth of Gram-negative and Gram-positive bacteria, such as Escherichia coli, Salmonella sp. and Staphylococcus epidermidis. PCL polymer was selected mainly because of its biodegradable aliphatic polyester characteristics and also, it plays a critical role in tissue engineering and pharmaceuticals. Scanning electron microscopy (SEM) images showed that the resultant fibers were in the range of 50 to 200 nm with an average diameter of 100 nm. Bacterial test results revealed that the gentamicin molecules in the nanofibers were gradually released from the PCL nanofibers during the in vitro tests and prevented bacterial growth at different inhibition zones and kinetics. Overall, this work provides a detailed explanation of how to improve the antibacterial properties of new drug delivery systems for many biomedical fields, such as scaffolding; drug, DNA, and protein delivery; and wound healing.en_US
dc.identifier.endpage51en_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://hdl.handle.net/11467/2878
dc.identifier.volume5en_US
dc.language.isoenen_US
dc.publisherBlue Penen_US
dc.relation.ispartofInternational Journal of Applied Microbiology and Biotechnology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGentamicinen_US
dc.subjectPCLen_US
dc.subjectElectrospinningen_US
dc.subjectNanofibersen_US
dc.subjectAntibacterialen_US
dc.titleEffects of gentamicin-loaded PCL nanofibers on growth of Gram positive and Gram negative bacteriaen_US
dc.typeArticleen_US

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