Effects of gentamicin-loaded PCL nanofibers on growth of Gram positive and Gram negative bacteria
Yükleniyor...
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Blue Pen
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Poly-?-caprolactones (PCLs) incorporated with gentamicin of different concentrations (0, 2.5, 5 and 10 wt.%) were electrospun under various conditions, and the resultant nanofibers of different thicknesses (1, 2 and 4 layers) were used against the growth of Gram-negative and Gram-positive bacteria, such as Escherichia coli, Salmonella sp. and Staphylococcus epidermidis. PCL polymer was selected mainly because of its biodegradable aliphatic polyester characteristics and also, it plays a critical role in tissue engineering and pharmaceuticals. Scanning electron microscopy (SEM) images showed that the resultant fibers were in the range of 50 to 200 nm with an average diameter of 100 nm. Bacterial test results revealed that the gentamicin molecules in the nanofibers were gradually released from the PCL nanofibers during the in vitro tests and prevented bacterial growth at different inhibition zones and kinetics. Overall, this work provides a detailed explanation of how to improve the antibacterial properties of new drug delivery systems for many biomedical fields, such as scaffolding; drug, DNA, and protein delivery; and wound healing.
Açıklama
Anahtar Kelimeler
Gentamicin, PCL, Electrospinning, Nanofibers, Antibacterial
Kaynak
International Journal of Applied Microbiology and Biotechnology Research
WoS Q DeÄŸeri
Scopus Q DeÄŸeri
Cilt
5
