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Öğe ASSESSING MYOCARDIAL DEFORMATION OF KAWASAKI PATIENTS WITH SPECKLE-TRACKING ECHOCARDIOGRAPHY ON LONG TERM FOLLOW UP(Bmj Publishing Group, 2016) Şahin, Sezgin; Dedeoğlu, Reyhan; Öztunç, Funda; Barut, Kenan; Cengiz, Dicle; Ugan Atik, Sezen; Kasapçopur, Özgür[Abstract Not Available]Öğe Erratum to: Evaluation of cardiac functions in juvenile systemic lupus erythematosus with two-dimensional speckle tracking echocardiography(Springer London, 2017) Dedeoğlu, Reyhan; Şahin, Sezgin; Koka, Aida; Öztunç, Funda; Cengiz, Dicle; Barut, Kenan; Kasapçopur, ÖzgürThe authors of the above article contacted the Journal on 29th March 2017, informing the Editor-in-Chief that they had discovered ethical approval was not requested from their Institutional Review Board (IRB) prior to performing the study discussed within the article. The authors explained that the omission of IRB approval resulted from miscommunication between the authorship group and a research fellow who left the group prior to the start of the study. Informed consent was received from all patients included in the study. The authors subsequently submitted a retrospective ethics approval request to their IRB, which was approved on 8th May, 2017. Given the non-invasive nature of the study, the Editors decided that the course of action by the authors was satisfactory. In the interests of transparency, the Journal and the authors wish to share the above with the Journal’s readers. © 2017, International League of Associations for Rheumatology (ILAR).Öğe Evaluation of cardiac functions in juvenile systemic lupus erythematosus with two-dimensional speckle tracking echocardiography(Springer London, 2016) Dedeoğlu, Reyhan; Şahin, Sezgin; Koka, Aida; Öztunç, Funda; Cengiz, Dicle; Barut, Kenan; Kasapçopur, ÖzgürThe aim of this study was to investigate subclinical systolic and diastolic dysfunction in juvenile-onset systemic lupus erythematosus (j-SLE) patients with speckle tracking echocardiography (STE) and the effects of disease activity on left ventricular (LV) regional functions. Thirty-five patients with j-SLE and 30 healthy children (control group) were evaluated between January and August 2015. STE was performed on all patients and controls. Medical records, including diagnosis criteria, age at diagnosis, and duration of disease, were evaluated. SLE disease activity was assessed using the SLE Disease Activity Index (SLEDAI). j-SLE patients had lower ejection fraction than did control subjects but still within normal range. LV end-diastolic and end-systolic dimensions were significantly larger in j-SLE patients (32.43 ± 3.2 vs 28.3 ± 3.1 and 21.1 ± 1.9 vs 18.9.0 ± 2.2, respectively; p = 0.001). There was a significant reduction in longitudinal strain of LV segments in the j-SLE patients compared with controls. J-SLE patients were further divided into subgroups. Group 1 comprised patients having SLEDAI scores >8 at the onset of disease but who improved with therapy during follow-up. Group 2 included j-SLE patients with SLEDAI scores >8 at diagnosis and persistently >4 at the end of follow-up. In the LV mid-inferior and mid-inferolateral segments, STE strain measurements of group 2 were significantly lower than those of group 1 (15.9 ± 6.4 vs 20.0 ± 4.4, 17.9 ± 7.2 vs 23.2 ± 3.8; p = 0.075, p = 0.055, respectively). Simple and non-invasive STE would be helpful in predicting cardiovascular prognosis with new therapeutic medications/interventions or in objectively comparing the effects of immunosuppressive drugs in comparison with preceding STE evaluation. © 2016, International League of Associations for Rheumatology (ILAR).Öğe Evaluation of myocardial deformation in patients with Kawasaki disease using speckle-tracking echocardiography during mid-term follow-up (vol 27, pg 1377, 2017)(Cambridge Univ Press, 2017) Dedeoğlu, Reyhan; Barut, Kenan; Öztunç, Funda; Atik, Sezen; Adrovic, Amra; Sahin, Sezgin; Cengiz, Dicle[Abstract Not Available]Öğe Evaluation of pulmonary artery pressure in patients with juvenile systemic lupus erythematosus (jSLE)(Association of Basic Medical Sciences of FBIH, 2018) Adrovic, Amra; Dedeoğlu, Reyhan; Şahin, Sezgin; Barut, Kenan; Koka, Aida; Cengiz, Dicle; Kasapçopur, ÖzgürJuvenile systemic lupus erythematosus (jSLE) is a chronic multisystemic autoimmune disease. Previous studies among adults have shown impaired right ventricular (RV) function in patients with SLE. Also, these patients may develop pulmonary artery hypertension (PAH), which is one of the most threatening complications of SLE. Nevertheless, studies on PAH among jSLE patients are still rare. The aim of this study was to assess the RV function in jSLE patients by Doppler echocardiography (Echo Doppler). We also estimated pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressure (mPAP) in these patients. A total of 38 jSLE patients and 40 sex- and age-matched controls were retrospectively analyzed. All patients underwent combined M-mode, cross-sectional echo, and Doppler Echo examination. The RV function was significantly impaired in jSLE patients compared to controls. PASP and mPAP were normal in 37 out of 38 patients (97.37%), however, the mean values of PASP and mPAP were significantly higher in jSLE patients compared to controls (26.90 mmHg versus 21.71 mmHg and 12.63 mmHg versus 9.89 mmHg, respectively) [p < 0.05]. Only one patient (2.6 %) had elevated mPAP (60 mmHg). The right cardiac catheterization confirmed PAH in this patient. Although PAH was detected only in one patient, there was a marked increase of PAP in our jSLE patients. Overall, PASP and mPAP were significantly higher in jSLE patients compared to healthy controls. Prospective studies with ethnically diverse cohorts could give more insight on the relevance of PAP and PHT in patients with jSLE. © 2018 ABMSFBIH.Öğe THE ICEBERG IN JUVENILE ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: SUBCLINICAL DETERIORATION OF CARDIAC FUNCTIONS ASSESSED WITH TWO-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHY AND CONTRIBUTING FACTORS OF SYSTOLIC DYSFUNCTION(Bmj Publishing Group, 2016) Şahin, Sezgin; Dedeoğlu, Reyhan; Adrovic, Amra; Öztunç, Funda; Barut, Kenan; Cengiz, Dicle; Kasapçopur, Özgür[Abstract Not Available]
