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    Studying the electrochemical behaviors of anodized metallic implants for improved corrosion resistance
    (İstanbul Ticaret Üniversitesi, 2022) Murad, Md. Shafinur; Usta, Aybala; Asmatulu, Ramazan; Ceylan, Muhammet
    A study about long-term corrosion behavior of anodized and non-anodized Ti6Al4V and MgAZ31B biomaterials was conducted under controlled conditions. By applying 20V DC potential, MgAZ31B alloys was anodized in phosphoric acid and potassium hydroxide while Ti6Al4V alloys was anodized in phosphoric acid and oxalic acid. Long-term experiments were carried out by immersing them in deionized (DI) water, 3% NaCl and phosphate-buffered saline (PBS) solutions. The corrosion rate and pattern were measured by electrochemical analysis. Also, as a result of anodization, the natural oxide layer was observed on the material surface, thus the corrosion rate is reduced and the life of the biomaterial has been improved.
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    Synthesis and evaluation of electrospun PCL-plasmid DNA nanofibers for post cancer treatments
    (Elsevier Ltd, 2022) Ceylan, Muhammet; Asmatulu, Ramazan; Jiang, Jianhao; Usta, Aybala; Jia, Tanghong; Yao, Li; Yang, Shang-you
    Poly-?-caprolactone (PCL) incorporated with plasmid DNA was electrospun, and the resultant nanofibers were used to observe DNA release from the nanofibers. The plasmid DNA enhanced green fluorescent protein (EGFP) with cytomegalovirus (CMV) promoter (PCMVb-GFP) was amplified with E. coli. PCL was chosen because it is biodegradable aliphatic polyester, which plays a critical role in tissue engineering, such as scaffolding, drug, DNA, gene and protein delivery vehicles. Some of the physical and biological properties of the nanofibers were determined using different methods. Scanning electron microscopy (SEM) micrographs showed that nanofibers have an average diameter of about 100 nm. Cytotoxicity tests showed that cell viability for 1 day, 4 days, and 7 days of the tests were above 80 %. These data demonstrated that PCL-plasmid DNA nanofibers have no cytotoxicity and showed benign biocompatibility for biomedical applications. PCMVb-GFP plasmid-linked electrospun nanofibers continuously released double-stranded DNA for at least seven days. For the first 15 min, there was a burst release of about 1.8 ng/ml. For the following hours and days, the release was about to be the same (release of 0.575 ng/ml). Therefore, PCL nanofibers may be an ideal candidate for various biomedical applications such as cancer treatment, scaffolding, tissue engineering, and protein delivery vehicles.