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Asymmetric dimethylarginine (ADMA) levels are increased in patients with fibromyalgia: Correlation with tumor necrosis factor-? (TNF-?) and 8-iso-prostaglandin F2? (8-iso-PGF2?)
(2011) Topal, Gökçe; Dönmez, Arif; Uydeş-Doğan, B.Sönmez; Kucur, Mine; Cengiz, Dicle; Berkoz, Fatma Begüm; Erdoğan, Nergis
Objective: The aim of the study was to investigate serum levels of asymmetric dimethylarginine (ADMA), tumor necrosis factor-? (TNF-?), interleukin-6 (IL-6) and plasma levels of 8-iso-prostaglandin F2? (8-iso-PGF2?) in patients with fibromyalgia. Design and method: Twenty-seven patients with fibromyalgia and twenty healthy controls were enrolled in this study. ADMA, TNF-?, IL-6 and 8-iso-PGF2? levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: Serum levels of ADMA and TNF-? and plasma levels 8-iso-PGF2? were significantly increased in patients with fibromyalgia compared to controls. However, no significant difference was observed in IL-6 levels between the two groups. ADMA concentrations were positively correlated with TNF-? and 8-iso-PGF2? levels in patients with fibromyalgia. Conclusion: This is the first study reporting that ADMA levels are significantly elevated in patients with fibromyalgia in association with increased 8-iso-PGF2? and TNF-? concentrations. Thereby, ADMA could be suggested as a reliable marker of endothelial dysfunction in patients with fibromyalgia. © 2011 The Canadian Society of Clinical Chemists.