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Synthesis, evaluation of antifungal activity and drug-likeness of benzoyl thiourea derivatives
(İstanbul Ticaret Üniversitesi, 2025) Erol Günal, Şule; Kaplan, Engin
Herein, we report the synthesis of a series of 2bromobenzoyl-substituted thiourea derivatives. The structures of the synthesized thioureas were characterized by spectroscopic methods. These derivatives, together with 2-fluorobenzoyl thioureas synthesized previously, have been evaluated for their potential antifungal activity. Compounds 2d and 2f showed antifungal activity against Candida albicans. Compound 2f also demonstrated activity against C. parapsilosis. Drug-likeness properties of the compounds were also estimated, and it was found that all compounds showed good drug-likeness properties.